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847~853.CAR-T细胞治疗实体肿瘤:且行且思考[J].魏建树,韩为东.中国肿瘤生物治疗杂志,2018,(9)
CAR-T细胞治疗实体肿瘤:且行且思考    点此下载全文    点此浏览HTML全文
魏建树  韩为东
中国人民解放军总医院基础医学研究所,北京100853
基金项目:国家自然科学基金资助项目(No.31270820、81230061、81502679、81703044) ;北京科技计划资助项目(No.Z151100003915076)
DOI:10.3872/j.issn.1007-385X.2018.09.001
摘要:
      [摘要] 由于T细胞免疫具有长效性、可放大性、多靶点性等特点,以T细胞为核心的肿瘤免疫治疗被认为是除手术外最有可能带来肿瘤治愈的治疗手段。尤其近年来不断累积的临床数据证实了以嵌合抗原受体修饰T(chimeric antigen receptor modified T, CAR-T)细胞为代表的细胞治疗的安全性与有效性,其中以CD19 为靶点的CAR-T细胞疗法由于效果显著,已成为多数临床研究机构开展基因修饰T细胞治疗研究的模式疗法。但是,实践和理论均显示,CAR-T细胞在实体肿瘤的治疗中面临着更严峻的挑战,如何更加合理有效的开展CAR-T细胞治疗实体肿瘤仍需要不断地探索。本文回顾了CAR-T细胞治疗临床实践历程、治疗实体瘤的现状,阐述了需要解决的问题及未来的发展方向,旨在为CAR-T细胞治疗实体肿瘤提供借鉴及研究思路。
关键词:嵌合抗原受体修饰T 细胞  实体肿瘤  微环境  脱靶毒性
CAR-T cell treatment of solid tumors:thoughts and practice    Download Fulltext
WEI Jianshu  HANWeidong
General Hospital of PLA, Institute of Basic Medicine, Beijing 100853, China
Fund Project:Project supported by the National Natural Science Foundation of China (No. 31270820、81230061、81502679、81703044), and the Science and Technology Program Funded by Beijing (No.Z151100003915076)
Abstract:
      [Abstract] Due to the long-lasting, scalable, multi-targeting characteristics of T-cell immunity, T-cell-based tumor immunotherapy is considered to be the most likely means of bringing about tumor healing in addition to surgery. Especially in recent years, accumulating clinical data have confirmed the safety and effectiveness of cell therapy represented by chimeric antigen receptor modified T (CAR-T) cell. Among these, CAR-T therapy targeting CD19 has become a model therapy for genetic modified T cell therapy research in most institutions because of its remarkable effects. However, both practice and theory have suggested that CAR-T therapy faces more complicated problems in the treatment of solid tumors. How to use CAR-T cells to treat solid tumors reasonably and effectively still requires constant exploration and understanding. Here, we briefly summarize the current status of clinical practice of CAR-T cell therapy and its treatment of solid tumors, propose problems that need to be solved, and discuss the future research directions, in order to provide reference and research ideas for the treatment of solid tumors by CAR-T cells.
Keywords:chimeric antigen receptor modified T (CAR-T) cell  solid tumor  microenvironment  off-target toxicity
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